Pancreatic metastasis in a case of small cell lung carcinoma: Diagnostic role of fine-needle aspiration cytology and immunocytochemistry

Pancreatic metastasis in a case of small cell lung carcinoma: Diagnostic role of fine-needle aspiration cytology and immunocytochemistry

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Small cell lung carcinoma represents a group of highly malignant tumors giving rise to early and widespread metastasis at the time of diagnosis.However, the pancreas is a relatively infrequent site of metastasis by this neoplasm, and there are only occasional reports on its fine needle aspiration (FNA) cytology diagnosis.A 66-year-old man presented with extensive mediastinal lymphadenopathy and a mass in the pancreatic tail.Ultrasound-guided FNA smears from the pancreatic sensationnel kiyari mass contained small, round tumor cells with extensive nuclear molding.

The cytodiagnosis was metastatic small cell carcinoma.Immunocytochemical staining showed that a variable number of neoplastic cell were positive for cytokeratin, canon imageclass mf227dw chromogranin A, neurone-specific enolase and synaptophysin but negative for leukocyte common antigen.The trans-bronchial needle aspiration was non-diagnostic, but biopsy was suspicious of a small cell carcinoma.This case represents a rare metastatic lesion in the pancreas from small cell lung carcinoma, diagnosed by FNA cytology.